                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE 
       INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

<130>  A-1221-WO-PCT

<140>  Not Assigned Yet
<141>  2007-12-17

<150>  60/875,706
<151>  2006-12-18

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His His His His His His Glu Ala Gly Arg Pro Arg Pro Val Leu 
1               5                   10                  15      


Arg Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg 
            20                  25                  30          


Ser Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro 
        35                  40                  45              


Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser 
    50                  55                  60                  


Tyr Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly 
65                  70                  75                  80  


Leu Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp 
                85                  90                  95      


Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys 
            100                 105                 110         


Glu Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr 
        115                 120                 125             


Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His 
    130                 135                 140                 


Pro Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala 
145                 150                 155                 160 


His Gln Arg Met Gly Asp 
                165     


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe Thr 
1               5                   10                  15      


Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val Glu 
            20                  25                  30          


Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp Asp 
        35                  40                  45              


Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr Ser 
    50                  55                  60                  


Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe Arg 
65                  70                  75                  80  


Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser Pro 
                85                  90                  95      


Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser Ala 
            100                 105                 110         


Asn Glu Gln Ala Val Gln 
        115             


<210>  3
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val Lys 
1               5                   10                  15      


Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met Leu Ser Gly 
            20                  25                  30          


Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn Phe Arg Glu 
        35                  40                  45              


Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe Thr Tyr Lys 
    50                  55                  60                  


Val Arg Tyr Thr Asn Ser Ser Thr Glu Ile Pro Glu Phe Pro Ile Ala 
65                  70                  75                  80  


Pro Glu Ile Ala Leu Glu Leu Leu Met Ala Ala Asn Phe Leu Asp Cys 
                85                  90                  95      


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinylation

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Carboxyamidated

<400>  4

Asp Leu Asp Leu Glu Ala Leu Ala Pro Tyr Ile Pro Ala Asp Asp Asp 
1               5                   10                  15      


Phe Gln Leu Arg 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinylation

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Carboxyamidated

<400>  5

Asp Leu Asp Leu Glu Ala Leu Ala Xaa Tyr Ile Pro Ala Asp Asp Asp 
1               5                   10                  15      


Phe Gln Leu Arg 
            20  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln 
1               5                   10                  15      


Leu 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Biotinylation

<400>  7

Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln 
1               5                   10                  15      


Leu 
    


